Scientists have found a new way of regeneration of hepatic cells.
The human liver can regenerate, but this requires at least 20% of healthy tissue.
Scientists while in the laboratory and using experimental mice, learned how to restore damaged by cirrhosis the liver by stimulating healthy cells to regenerate body with non-infectious AAV virus.
Writes United Press International, experimental methods of recovery of damaged liver was developed by the University of California. The human liver can regenerate, but this requires at least 20% of healthy tissue.
Often the only way of salvation is the transplantation of organ tissues, however the donor is not enough. According to the Professor of surgery Holger Willenbring from the University of California, in the next 10 years fatty liver is a consequence of obesity – will be the main reason for the development of cirrhosis.
Meanwhile, scientists will test a way to do without donors and transplantation. They used AAV virus is harmless to humans and causes a small immune response, to reprogram the DNA of developing cirrhosis cells making hepatocytes from healthy cells, promoting regeneration of the body.
In experiments with laboratory mice, the researchers found that the reprogrammed cells began to spread, improving liver function and reducing fibrosis. Also raised the experience with a human liver, but here scientists have noted that “much work remains”. The main difficulty now is to determine spreading fibrosis cells.
